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Cytosolic copper enters mitochondria through the cytosolic anionic ligand (CuL) complex or binds to copper chaperone proteins, including copper chaperone for superoxide dismutase (CCS), human antioxidant protein 1, and cytochrome c oxidase copper chaperone 17, before being transferred to copper-storing proteins such as COX1, copper metallothionein 1, and superoxide dismutase [Cu-Zn] (SOD1)

Verma P, Pathak K

Applications and delivery mechanisms of hyaluronic acid used for topical/transdermal deliverya review[J]

The most studied copper peptide is GHK-Cu (glycyl-L-histidyl-L-lysine), a small copper-binding peptide, naturally present in human plasma

If it does occur, it can be corrected by dissolving the filler with hyaluronidase

Lenney W, Fryer AA